This study aimed to determine the acute and subacute toxicities of vitamin C on mice and rabbits. The results showed that: (1) In acute toxicity study, the oral LD50 dose for vitamin C was 12.700 ± 370 mg/kg in mice (approximately 590 times as many as usual dose on human); (2) In subacute toxicity study, the daily oral vitamin C at the doses of 300 mg and 600 mg/kg/body weight per day was given to rabbits for 42 days. No significant changes were found in animal weights, electrocardiogram, haematological parameters, liver parameters (AST and ALT) and renal parameters (urea and creatinine). No pathological changes were observed in the rabbit’s liver, kidneys and spleen. Our data suggest that oral vitamin C manufactured by Vietnam Institute of Industrial Chemistry has low toxicity and high safety. Download Link: eBook có trong tuyển tập DVD Y Học http://hocvienquany.vn/Tapchi/Data/TapTin/2012_4_1bach thi tam.pdfhttps://www.mediafire.com/?hntqghhkmizgiq
